http://newindpress.com

washington: a component of green tea may lead to clinical improvement in patients with chronic lymphocytic leukemia (cll), according to a new study published in leukemia research by mayo clinic researchers.

in the small case study, the researchers report on four patients who appeared to have an improvement in the clinical state of their disease after starting over-the-counter products containing epi gallo catechin gallate (egcg), an extract of green tea. three of the four patients met the standard criteria used to define a response treatment for clinical trials.

these same investigators had previously shown that egcg kills leukemia cells from patients with cll in the test tube by interrupting the communication signals they need to survive.

"the experience of these individuals provides some suggestion that our previously published laboratory findings may actually translate into clinical effects for patients with this disease," says tait shanafelt, lead author of the article.

"we do not know how many patients were taking similar products and failed to have any benefit. we also do not yet know the optimal dose that should be used, the frequency with which patients should take the medication, and what side effects will be observed with long-term administration," he cautions.

cll is a blood and bone marrow cancer. it is called chronic leukemia because it progresses more slowly than acute leukemia, and lymphocytic because it affects a group of white blood cells (lymphocytes), which typically fight infection.

cll has no known cure and affects each individual differently. some patients may live with it for decades and not require treatment, while others need immediate chemotherapy, and some die within months despite therapy. because the course of the cll is so variable, physicians have historically adopted an attitude of watchful waiting with early-stage cll patients.

however, new tests, new medications and a better understanding of the disease have stimulated interest in clinical trials to evaluate whether options beyond watchful waiting will better serve some patients.

"green tea has long been thought to have cancer-prevention capabilities. it is exciting that research is now demonstrating this agent may provide new hope for cll patients," said dr. shanafelt.